On both MednafenX-NES and PCE, I set the aspect ratio to how I want it and save it (both 720p and 1080i). I go back into the aspect ratio option and it looks good. Once I start a game or restart the emulator, the screen size changes back to the default, tiny size in the upper left hand corner. I go into each game profile in the E:\Saves folder and delete the .key file for each game to make sure that there's no overriding screen size for the games.

Am I missing something or what do I need to do to get the screen size and location to stick in either of the emulators?