I get the same error on Legacy of Kain: Defiance. I have tried deleting the game and reinstalling it with PxHDD Loader and it gives me the same error... but it is somewhat random.
I have a 4979 bios too so im not sure what to do ;(
EDIT: I just wanted to say that I looked at the freezing tutorial and followed it ;p I've tried reinstalling from scratch, deleting cache, deleting save games, all my IGRs are off (all 3), and my bios is up to date. XBox 1.5 :/