Maniac Mansion Deluxe has been made with AGS (adventure game studio)
so it would need the AGS source,
however last time i checked the source to AGS was not available.
you can however try to run the linux version of AGS and then run the game with that.
(i don't know if you will need a special linux version of the game though)
(edit : yep, i'm pretty sure you will need a linux version, which as far as i know does not exist)
(edit2 : and don't bother contacting the creator of MMD, he went underground after Lucasarts sued someone about something so he decided to get out before they came after him)
also wrong forum, this is homebrew related not emulation.