I am running an original copy of GH2 and it has worked flawlessly up to this point (disk isn't scratched much at all). Now, for some unknown reason some of the sounds are missing (when the guitar player throws down the guitar, when you miss a note and flipping through the menu). I have looked around and haven't seen anyone with a similar problem. I haven't tried deleting all of my game data because I have nowhere to back it up.

Has anyone else run into this problem?

does anyone else use your system? perhaps hit the start button in the middle of the song. check the audio options. it sounds like someone turned your sound effects slider down from 11 to 0.